Vicente Duarte commits his first crime. The victim is a young, attractive woman whom the criminal had never met. From his initial foray into the world of crime, Duarte feels a kind of inner serenity, which will drive him to continue committing more crimes.

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Susana has gathered all her friends to celebrate a very special evening: it's Toni's birthday, and for the first time he's away in Germany, but the distance is not going to stop them from celebrating together. No one suspects that after the party their lives will change forever.

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Diana Cervantes is a simple and lukewarm secretary to Andrés Lascurain, since she seeks the love of her life when she is hired, she falls in love with Andrés, enduring the misdeeds and injustices of Denisse, who is committed to Andrés, to be his future wife. Andrés and Diana marry leaving Denisse out of her life, while she is an accomplice and lover of Roberto Meráz, who has a dark past with Andrés and has a desire to take revenge. Andres has a family with his late wife (as believed dead) made up of the children Elisa, Claudia, Andresito, Alex's rebel and the deceased's evil sister, Soledad. Andres and Diana are going to face many events such as the threat of Denisse Junot and Roberto Meráz. Denisse dies at the hands of Olympus when he learns that he betrayed him, he gives Denisse's son to his daughter Soledad.

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Secretos de Familia is a Mexican telenovela, remake of Brothers & Sisters by Azteca in 2013. As of January 2013, confirmed cast includes Sergio Basañez and Anette Michel as the protagonists. As of May 13, 2013, Azteca 13 is broadcasting Secretos de Familia, replacing La Otra Cara del Alma.